Higher fish consumption may be associated with increased risk of melanoma

According to a large study published in Cancer causes and control.

Eunyoung Cho, the corresponding author, said, “Melanoma is the fifth most common cancer in the United States, and the lifetime risk of developing melanoma is one in 38 for whites, one in 1,000 for blacks and one in 167 for Hispanics.1. Although fish consumption has increased in the United States and Europe in recent decades, results from previous studies investigating associations between fish consumption and melanoma risk have been inconsistent. Our findings have identified an association that requires further investigation.”

Researchers at Brown University in the United States found that compared to those whose median daily fish consumption was 3.2 grams, the risk of malignant melanoma was 22% higher in those whose consumption median daily was 42.8 grams. They also found that those with a median daily intake of 42.8 grams of fish had a 28% increased risk of developing abnormal cells in the outer layer of the skin only – known as stage 0 melanoma. or melanoma in situ – compared to those whose median daily intake was 3.2 grams of fish. A portion of fish corresponds to approximately 140 grams of cooked fish.

To examine the relationship between fish consumption and melanoma risk, the authors analyzed data collected from 491,367 adults recruited across the United States for the NIH-AARP Diet and Health Study between 1995 and 1996. The participants, aged 62 on average, reported how often they ate fried fish, unfried fish and tuna in the previous year, as well as their portion sizes.

The researchers calculated the incidence of new melanomas that developed over a median period of 15 years using data obtained from cancer registries. They took into account socio-demographic factors, as well as participants’ BMI, physical activity levels, smoking history, daily alcohol, caffeine and calorie consumption, family history of cancer and average levels of UV radiation in their area. 5034 participants (1.0%) developed malignant melanoma during the study period and 3284 (0.7%) developed stage 0 melanoma.

Researchers found that higher consumption of unfried fish and tuna was associated with increased risks of malignant melanoma and stage 0 melanoma. Those with a median daily tuna consumption of 14.2 grams had an increased risk 20% higher malignant melanoma and 17% higher risk of stage 0 melanoma, compared to those whose median daily tuna consumption was 0.3 grams. A median consumption of 17.8 grams of unfried fish per day was associated with an 18% higher risk of malignant melanoma and a 25% higher risk of stage 0 melanoma, compared to a median consumption of 0.3 gram of unfried fish per day. . The researchers did not identify any significant associations between fried fish consumption and the risk of malignant melanoma or stage 0 melanoma.

Eunyoung Cho said, “We think our findings could possibly be attributed to contaminants in the fish, such as polychlorinated biphenyls, dioxins, arsenic and mercury. elevated is associated with higher levels of these contaminants in the body and has identified associations between these contaminants and a higher risk of skin cancer.However, we note that our study did not investigate the levels of these contaminants in the bodies of participants and therefore further research is needed to confirm this relationship.

The researchers caution that the observational nature of their study does not allow conclusions to be drawn about a causal relationship between fish consumption and melanoma risk. They also did not consider certain risk factors for melanoma, such as number of moles, hair color, history of severe sunburn and sun-related behaviors in their analyses. Also, because the average daily fish intake was calculated at the start of the study, it may not be representative of participants’ lifetime diets.

The authors suggest that future research is needed to investigate components of fish that may contribute to the observed association between fish consumption and melanoma risk and any underlying biological mechanisms. At this time, they do not recommend any changes to fish consumption.

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